Well, it looks like the carpooling race in Europe continues. BlaBlaCar, the European carpooling marketplace and competitor to Carpooling.com, has announced that it's reached the milestone of 3 million members, almost double from this time last year. It's also expanding to Germany, giving testimony to being a truly pan-European player.Source: http://feedproxy.google.com/~r/Techcrunch/~3/7Znhnp2KrWQ/
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Gregg Fraley and I both are? of the opinion that a non-creative innovation consultant who knows the theory, but doesn?t get his hands dirty, has no business in giving game-changing advice.
Via Gregg Fraley in response to this article about creativity gurus:
Interesting that even the experts don?t really know how, exactly, to be more creative. A nicely written, humorous, and thoughtful piece.
When I saw his response, I couldn?t help myself and not respond. Here is my on-going response with Gregg (from Facebook):
Not difficult to separate the posers from the rest. Litmus test question: If you are not innovative with self, then how you can you help others become innovative?
I respect people who walk the talk. If you behave this way, it means you are not afraid to fail. How much is a non-creative creativity consultant risking by regurgitating what is being said in books and everywhere else? Nothing.
Also, innovation is about making things better, and if the person who is advising/challenging you on how to make things better doesn?t act this way, then he/she has no business giving advice on what they don?t do themselves.
I know a couple of people in my neck of the woods who ?sell innovation? and know for a fact that they are running around with frameworks from other people. For me, if you are truly committed to innovation, then you have to challenge the status-quo. That means best practices. And, if you can?t identify when you are simply regurgitating best practices, then why would I expect you to challenge and stretch my thinking?
YES! I?ve never had a great idea come out of using frameworks and tools. Nor have I heard of any game-changing business be born in a strategic planning session where frameworks were used. I understand their value in helping people think, but, true advantage is cognitive.
Tools don?t make a great mind, but a fluid and adaptable mind makes frameworks irrelevant.
Of course, this is a daunting challenge for anyone and even more daunting for an organization.
Do you think creativity/innovation consultants should be held to a higher standard?
Source: http://www.game-changer.net/2013/04/09/should-innovation-consultants-be-innovators-themselves/
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Public release date: 10-Apr-2013
Share ] Contact: Emily Eng
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MANHASSET, NY The Feinstein Institute for Medical Research today unveiled a collaboration with the University of Pennsylvania and Massachusetts Institute of Technology (MIT) being spearheaded by GlaxoSmithKline (GSK), which aims to discover medicines that use electrical impulses to regulate the body's organs and functions. This initiative is discussed in the April issue of Nature.
"This is a powerful collaboration between leaders in the field of medical device development," said Kevin J. Tracey, MD, president of the Feinstein Institute. "We are focused on developing implantable electrical devices as treatments for disease. It is likely that miniaturized, computerized technologies that target neurons will someday replace existing drugs this has the potential to be revolutionize how we think about helping patients."
Nearly all organs and functions in the body are regulated through circuits of neurons that communicate through electrical impulses. There already exist devices that use electrical impulses to treat disease (i.e., pacemakers, defibrillators, deep-brain stimulation), but these devices do not target specific cells in the body. Researchers now believe it is possible to create devices that control action potentials in individual neurons, a critical step in developing technologies to use neural circuits to control specific cells. It may be possible to intervene in a broad spectrum of diseases, like inflammatory and autoimmune diseases, because these conditions can be controlled by neurons.
The collaboration between the Feinstein Institute, GSK, MIT and University of Pennsylvania will dedicate resources with the aim to discover electrical impulse medical treatment (electroceuticals). Specifically, the Feinstein Institute will continue research on the neural codes that underlie diseases of immunity and inflammation to identify intervention points and conduct exploratory clinical work. Initial results have already shown that it is possible to manipulate neural signals specific to different inflammatory mediators in standard laboratory models.
###
About The Feinstein Institute for Medical Research
Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research is home to international scientific leaders in many areas including Parkinson's disease, Alzheimer's disease, psychiatric disorders, rheumatoid arthritis, lupus, sepsis, human genetics, pulmonary hypertension, leukemia, neuroimmunology, and medicinal chemistry. The Feinstein Institute, part of the North Shore-LIJ Health System, ranks in the top 5th percentile of all National Institutes of Health grants awarded to research centers. For more information visit http://www.FeinsteinInstitute.org
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 10-Apr-2013 Share ] Contact: Emily Eng
eng3@nshs.edu
516-562-2670
North Shore-Long Island Jewish (LIJ) Health System
MANHASSET, NY The Feinstein Institute for Medical Research today unveiled a collaboration with the University of Pennsylvania and Massachusetts Institute of Technology (MIT) being spearheaded by GlaxoSmithKline (GSK), which aims to discover medicines that use electrical impulses to regulate the body's organs and functions. This initiative is discussed in the April issue of Nature.
"This is a powerful collaboration between leaders in the field of medical device development," said Kevin J. Tracey, MD, president of the Feinstein Institute. "We are focused on developing implantable electrical devices as treatments for disease. It is likely that miniaturized, computerized technologies that target neurons will someday replace existing drugs this has the potential to be revolutionize how we think about helping patients."
Nearly all organs and functions in the body are regulated through circuits of neurons that communicate through electrical impulses. There already exist devices that use electrical impulses to treat disease (i.e., pacemakers, defibrillators, deep-brain stimulation), but these devices do not target specific cells in the body. Researchers now believe it is possible to create devices that control action potentials in individual neurons, a critical step in developing technologies to use neural circuits to control specific cells. It may be possible to intervene in a broad spectrum of diseases, like inflammatory and autoimmune diseases, because these conditions can be controlled by neurons.
The collaboration between the Feinstein Institute, GSK, MIT and University of Pennsylvania will dedicate resources with the aim to discover electrical impulse medical treatment (electroceuticals). Specifically, the Feinstein Institute will continue research on the neural codes that underlie diseases of immunity and inflammation to identify intervention points and conduct exploratory clinical work. Initial results have already shown that it is possible to manipulate neural signals specific to different inflammatory mediators in standard laboratory models.
###
About The Feinstein Institute for Medical Research
Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research is home to international scientific leaders in many areas including Parkinson's disease, Alzheimer's disease, psychiatric disorders, rheumatoid arthritis, lupus, sepsis, human genetics, pulmonary hypertension, leukemia, neuroimmunology, and medicinal chemistry. The Feinstein Institute, part of the North Shore-LIJ Health System, ranks in the top 5th percentile of all National Institutes of Health grants awarded to research centers. For more information visit http://www.FeinsteinInstitute.org
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/nsij-fic041013.php
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BEIRUT (AP) ? Al-Qaida's branch in Iraq said it has merged with Syria's extremist Jabhat al-Nusra, a move that shows the rising confidence of radicals within the Syrian rebel movement and is likely to trigger renewed fears among its international backers.
A website linked to Jabhat Al-Nusra confirmed on Tuesday the merger with the Islamic State of Iraq, whose leader Abu Bakr al-Baghdadi first made the announcement in a 21-minute audio posted on militant websites late Monday.
Jabhat Al-Nusra has taken an ever-bigger role in Syria's conflict over the last year, fighting in key battles and staging several large suicide bombings. The U.S. has designated it a terrorist organization.
The Syrian group has made little secret of its ideological ties to the global jihadist movement and its links across the Iraqi border but until now has not officially declared itself to be part of al-Qaida.
Al-Baghdadi said that his group ? the Islamic State of Iraq ? and Syria's Jabhat al-Nusra will now be known as the Islamic State in Iraq and Sham. Sham is a name for Syria and the surrounding region.
"It is time to announce to the Levantine (Syrian) people and the whole world that Jabhat al-Nusra is merely an extension and part of the Islamic State of Iraq," he said.
He said that the Iraqi group was providing half of its budget to the conflict in Syria. Al-Baghdadi said that the Syrian group would have no separate leader but instead be led by the "people of Syria themselves" ? implying that he would be in charge in both countries.
For such a high-profile Syrian rebel group to formally join al-Qaida is likely to spark concerns among backers of the opposition that are in the global terror network's crosshairs, including both Western countries and Gulf Arab states.
It may increase resentment of Jabhat al-Nusra among other rebel groups. Rebels have until now respected Nusra fighters for their prowess on the battlefield but a merger with al-Qaida will complicate any effort to send them arms from abroad.
A website linked with Jabhat al-Nusra known as al-Muhajir al-Islami ? the Islamic emigrant ? confirmed the merger.
The authenticity of neither message could be independently confirmed, but statements posted on major militant websites are rarely disputed by militant groups afterward.
Jabhat al-Nusra emerged as an offshoot of Iraq's al-Qaida branch in mid-2012 as one of a patchwork of disparate rebel groups in Syria.
One of the most dramatic attacks by the groups came on March 4, when 48 Syrian soldiers were killed in a well-coordinated ambush after seeking refuge across the border in Iraq following clashes with rebels in their home country. The attack occurred in Iraq's restive western province of Anbar, where al-Qaida is known to be active.
A top Iraqi intelligence official told The Associated Press in Baghdad that they have always known that "al-Qaida in Iraq is directing Jabhat al-Nusra."
He said they announced their unity because of "political, logistical and geographical circumstance." The official said Iraqi authorities will take "strict security measures to strike them."
Iraqi officials say the jihadi groups are sharing three military training compounds, logistics, intelligence and weapons as they grow in strength around the Syria-Iraq border, particularly in a sprawling region called al-Jazeera, which they are trying to turn into a border sanctuary they can both exploit. It could serve as a base of operations to strike either side of the border.
Baghdad officials said last week they have requested U.S. drone strikes against the fighters in Iraqi territory. A U.S. official confirmed that elements within the Iraqi government had inquired about drone strikes. But the official said the U.S. was waiting to respond until the top level of Iraqi leadership makes a formal request, which has not happened yet.
All officials spoke anonymously as they were not authorized to give official statements to the media
Eastern Syria and western Iraq have a predominantly Sunni Muslim population like most of the rebels fighting President Bashar Assad, who belongs to the minority Alawite Sect, an offshoot of Shiite Islam. The Baghdad government is dominated by Shiites, who are majority in Iraq.
The announcement came hours after a suicide car bomber struck Monday in the financial heart of Syria's capital, killing at least 15 people, damaging the nearby central bank.
No one has claimed responsibility for the attack but such operations were claimed by Jabhat al-Nusra in the past.
Activists reported violence in different parts of Syria on Tuesday.
The Britain-based Syrian Observatory for Human Rights reported air raids on suburbs of the capital Damascus as well as the northern province of Raqqa and Idlib.
Syria's crisis, which began in March 2011 with protests calling for Assad's ouster, then evolved into a civil war. The U.N. says more than 70,000 have been killed in the conflict.
_____
Youssef reported from Cairo. Associated Press writer Qassim Abdul-Zahra contributed to this report from Baghdad.
Source: http://news.yahoo.com/iraqi-al-qaida-syria-militants-announce-merger-114411187.html
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Google has spent the past couple years facing down antitrust accusations in Europe for pushing its web services over those of competitors. But, just as that case is coming to a close, the New York Times now reports that new anti-competitive allegations have been levied against Android. This new complaint was filed by a group called Fairsearch -- whose members include old EU foes Microsoft and Nokia, plus Oracle and a host of travel booking websites -- and claims that Google's using Android as a way to deceive consumers into using Google apps instead of competitors' software. The problem, as Fairsearch sees it, is that Google forces OEMs who use Android to unfairly place apps like YouTube and Gmail in prominent places on the desktop. Of course, this new complaint is just the beginning, so we'll have to wait and see what the European Commission's investigation into the matter uncovers, and how the folks in Mountain View respond.
Filed under: Microsoft, Nokia, Google
Source: New York Times
Source: http://www.engadget.com/2013/04/08/eu-antitrust-complaint-google-android/
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FRANKFORT, Ky. (AP) ? Campaign aides to Senate Republican Leader Mitch McConnell proposed using actress Ashley Judd's past bouts with depression against her if she had decided to challenge him in his re-election bid next year, according to a secret recording posted by a magazine.
Mother Jones released a recording Tuesday along with an article about a private meeting in which the aides discussed opposition research into potential Democratic challengers. Aides talked and laughed on the recording about Judd's political positions, religious beliefs and past bouts of depression.
The FBI is looking into how the recording was made after the McConnell campaign accused opponents of engaging in "Watergate-era tactics." The magazine reported that the recording was provided last week by a source who requested anonymity.
"She's clearly ? this sounds extreme ? but she is emotionally unbalanced," a McConnell aide said of Judd during a February meeting at the Louisville campaign headquarters. "I mean it's been documented ... she's suffered some suicidal tendencies. She was hospitalized for 42 days when she had a mental breakdown in the '90s."
Judd has been open about her bouts with depression. She spoke to the American Counseling Association's national convention in Cincinnati in March, telling more than 3,000 counselors from across the country about her experiences. Her spokeswoman, Cara Tripicchio, criticized the McConnell campaign for considering making it a campaign issue.
"This is yet another example of the politics of personal destruction that embody Mitch McConnell and are pervasive in Washington DC," Tripicchio said in a statement. "We expected nothing less from Mitch McConnell and his camp than to take a personal struggle such as depression, which many Americans cope with on a daily basis, and turn it into a laughing matter."
McConnell was asked several times at a news conference Tuesday about the propriety of attacking Judd over depression. He did not directly answer, but repeatedly brought up an incident last month, when Progress Kentucky tweeted an insensitive remark about his wife, former Labor Secretary Elaine Chao.
"As you know, my wife's ethnicity was attacked by a left-wing group in Kentucky and apparently they also bugged my headquarters," he said. "So I think that pretty well sums up the way the political left is operating in Kentucky."
The FBI confirmed that it was contacted by McConnell's office and was looking into the matter. The magazine didn't return a call seeking comment.
McConnell campaign manager Jesse Benton alleged in an email to supporters that "liberals and their media allies" were "wire-tapping our field office to spy on us," even though it wasn't clear how the recording was obtained. Benton used the issue as a fundraising appeal, asking supporters to send donations "to help us spread the truth."
On the recording posted on Mother Jones' website, McConnell began the meeting by telling aides the campaign had entered "the Whac-A-Mole period" and explained that means "when anybody sticks their head up, do them out."
The magazine reported the aides huddled on Feb. 2 in a private meeting to discuss potential Democratic opponents, including Judd and Kentucky Secretary of State Alison Lundergan Grimes. Grimes, a rising star within the Kentucky Democratic Party, hasn't ruled herself out as a challenger.
An unidentified aide said Judd had made a public statement as a Tennessee delegate to the Democratic national convention about her support of President Barack Obama, an unpopular figure in Kentucky. The aide said that statement could be used against her and raised another issue: Judd lives in Tennessee, not Kentucky.
In another instance, the aide played a recording of Judd talking about her evolving religious beliefs, which included native faith practices. The aides laugh loudly. An unidentified man then says "the people at Southeast Christian would take to the streets with pitchforks," referring to an evangelical megachurch in Louisville.
The magazine was the first to report about Republican Mitt Romney's comments to donors paying $50,000 apiece to attend a private reception that 47 percent of Americans are dependent on government, see themselves as victims and believe the government has a responsibility to care for them.
Romney's critics used the video to argue that he was out of touch with average Americans during the last presidential campaign.
Kentucky Democratic Party Chairman Dan Logsdon said the recording is telling about McConnell.
"I certainly do not know anything about how this may have happened," Logsdon said. "However, it's clear that this is the McConnell we all know: leading a negative, nasty campaign determined to lash out at his opponents since he doesn't have any accomplishments to point to."
___
Associated Press writers Jim Abrams and Donna Cassata in Washington and Brett Barrouquere in Louisville contributed to this report.
Source: http://news.yahoo.com/fbi-investigating-recording-mcconnell-talks-190453229--election.html
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With all this talk about the cord-cutting masses no longer wanting to subsidize TV channels they don't watch, it's a little surprising that one of the oldest, most widely available forms of TV is waning: over-the-air broadcast TV. Despite its attractive price of $0 per month and billions of advertising revenue, nobody ? including the broadcast networks, the tech companies that are out to disrupt them, and the cord-cutters and cord-nevers who hate cable ? is very enthusiastic about antennas. ...
Source: http://news.yahoo.com/htc-seen-losing-window-opportunity-htc-one-component-182544158.html
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Apr. 8, 2013 ? Taking an approach similar to that used for discovering new therapeutic drugs, chemists at the University of California, Davis, have found several compounds that can boost oil production by green microscopic algae, a potential source of biodiesel and other "green" fuels.
The work appears online in the journal Chemical Biology.
Microalgae are single-celled organisms that, like green plants, use photosynthesis to capture carbon dioxide and turn it into complex compounds, including oils and lipids. Marine algae species can be raised in saltwater ponds and so do not compete with food crops for land or fresh water.
"They can live in saltwater, they take sunlight and carbon dioxide as a building block, and make these long chains of oil that can be converted to biodiesel," said Annaliese Franz, assistant professor of chemistry and an author of the paper.
Franz, graduate students Megan Danielewicz, Diana Wong and Lisa Anderson, and undergraduate student Jordan Boothe screened 83 compounds for their effects on growth and oil production in four strains of microalgae. They identified several that could boost oil production by up to 85 percent, without decreasing growth.
Among the promising compounds were common antioxidants such as epigallocatechin gallate, found in green tea, and butylated hydroxyanisole (BHA), a common food preservative.
The team has carried out growth experiments in culture volumes of up to half a liter. They calculate that some of the chemicals they analyzed would be cost-effective when scaled up to a 50,000 liter pond. After oils have been extracted from the algae, the remaining mass can be processed for animal feed or other uses.
Franz came to UC Davis in 2007 with a background in pharmaceutical chemistry. Given the campus's emphasis on biofuels, she started thinking about applying high-throughput techniques used to screen for new drugs to looking for compounds that could affect microalgae.
The idea, Franz said, is to look for small molecules that can affect a metabolic pathway in a cell. By setting up large numbers of cell cultures and measuring a simple readout in each, it's possible to screen for large numbers of different compounds in a short time and home in on the most promising.
"The basic concept comes from the pharmaceutical industry, and it's been used for human cells, plants, yeast, but not so far for algae," she said.
"There are many cases where small molecules are having an effect to treat a disease, so it makes sense that if you can affect a pathway in a human for a disease, you can affect a pathway in an algal cell," Franz said.
Patents on the work are pending. The research was funded by Chevron Technology Ventures through a cooperative agreement with UC Davis.
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To ring in this year's Holocaust Memorial Day, the classy hackers at Anonymous took down a bunch of Israeli government websites on Sunday and say they caused over $3 billion in damage. But they didn't totally get away with it. Within a few hours of the attack which Anonymous says affected 100,000 websites, 40,000 Facebook pages, 5,000 Twitter accounts and 30,000 bank accounts, an Israeli hacker broke into the website that Anonymous had set up for the attack, dubbed Operation Israel. ...
Source: http://news.yahoo.com/kuwait-telco-zain-keen-libya-market-chairman-103626000--finance.html
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Apr. 7, 2013 ? A new separation process that depends on an easily-distinguished physical difference in adhesive forces among cells could help expand production of stem cells generated through cell reprogramming. By facilitating new research, the separation process could also lead to improvements in the reprogramming technique itself and help scientists model certain disease processes.
The reprogramming technique allows a small percentage of cells -- often taken from the skin or blood -- to become human induced pluripotent stem cells (hiPSCs) capable of producing a wide range of other cell types. Using cells taken from a patient's own body, the reprogramming technique might one day enable regenerative therapies that could, for example, provide new heart cells for treating cardiovascular disorders or new neurons for treating Alzheimer's disease or Parkinson's disease.
But the cell reprogramming technique is inefficient, generating mixtures in which the cells of interest make up just a small percentage of the total volume. Separating out the pluripotent stem cells is now time-consuming and requires a level of skill that could limit use of the technique -- and hold back the potential therapies.
To address the problem, researchers at the Georgia Institute of Technology have demonstrated a tunable process that separates cells according to the degree to which they adhere to a substrate inside a tiny microfluidic device. The adhesion properties of the hiPSCs differ significantly from those of the cells with which they are mixed, allowing the potentially-therapeutic cells to be separated to as much as 99 percent purity.
The high-throughput separation process, which takes less than 10 minutes to perform, does not rely on labeling technologies such as antibodies. Because it allows separation of intact cell colonies, it avoids damaging the cells, allowing a cell survival rate greater than 80 percent. The resulting cells retain normal transcriptional profiles, differentiation potential and karyotype.
"The principle of the separation is based on the physical phenomenon of adhesion strength, which is controlled by the underlying biology," said Andr?s Garc?a, the study's principal investigator and a professor in Georgia Tech's Woodruff School of Mechanical Engineering and the Petit Institute for Bioengineering and Bioscience. "This is a very powerful platform technology because it is easy to implement and easy to scale up."
The separation process was described April 7 in the advance online publication of the journal Nature Methods. The research was supported by the National Institutes of Health (NIH) and the National Science Foundation (NSF), supplemented by funds from the American Recovery and Reinvestment Act (ARRA).
"The scientists applied their new understanding of the adhesive properties of human pluripotent stem cells to develop a quick, efficient method for isolating these medically important cells," said Paula Flicker, of the National Institutes of Health's National Institute of General Medical Sciences, which partly funded the research. "Their work represents an innovative conversion of basic biological findings into a strategy with therapeutic potential."
An improved separation technique is essential for converting the human induced pluripotent stem cells produced by reprogramming into viable therapies, said Todd McDevitt, an associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, and director of Georgia Tech's Stem Cell Engineering Center.
"For research purposes, depending on labeling reagents for separation is not a major problem," said McDevitt, one of the paper's co-authors. "But when we move into commercialization and manufacturing of cell therapies for humans, we need a technology approach that is unbiased and able to be scaled up."
The separation technique, called micro stem cell high-efficiency adhesion-based recovery (?SHEAR), will allow standardization across laboratories, providing consistent results that don't depend on the skill level of the users. "Because of the engineering and technology involved, and the characterization work, we now have a technology that is readily transferrable," McDevitt said.
The ?SHEAR process grew out of an understanding of how cells involved in the reprogramming process change morphologically as the process proceeds. Using a spinning disk device, the researchers tested the adhesive properties of the hiPSCs, the parental somatic cells, partially-reprogrammed cells and reprogrammed cells that had begun differentiating. For each cell type, they measured its "adhesive signature" -- the level of force required to detach the cells from a substrate that had been coated with specific proteins.
The research team, which included Georgia Tech postdoctoral fellows Ankur Singh and Shalu Suri, tested their technique in microfluidic devices developed in collaboration with Hang Lu, a professor in Georgia Tech's School of Chemical and Biomolecular Engineering.
In the testing, cells from the culture were first allowed to attach to the substrate before being subjected to the flow of buffer fluid. Cells with a lower adhesive signature detached from the substrate at lower flow rates. By varying the flow rate, the researchers were able to separate specific types of cells, allowing production of stem cell cultures with purity as high as 99 percent -- from mixtures in which those cells accounted for only a few percent of the total.
"At different stages of reprogramming, we see differences in the molecular composition and distribution of the cellular structures that control adhesion force," Garc?a explained. "Once we know the range of adhesive forces for each cell type, we can apply those narrow ranges to select the populations that come off in each range."
Using inexpensive disposable "cassettes," the microfluidic system could be scaled up to increase the volume of cells produced and to provide specific separations, Garc?a noted.
Unlike existing labeling techniques, the new separation process works on cell colonies, avoiding the need to risk damaging cells by breaking up colonies for separation. The separation process has been tested with both reprogrammed blood and skin cells. Cells were provided for testing by ArunA Biomedical, a company based in Athens, Ga., founded by University of Georgia professor Steven Stice.
Beyond the direct application in producing stem cells, the separation technique could also help scientists with other research in which cells need to be separated -- including potential improvements in the reprogramming technique, which won the Nobel Prize for medicine in 2012.
"Cell reprogramming has been a black box," said McDevitt. "You start the reprogramming process, and when the cells are fully reprogrammed, you can pick them out visually. But there are really interesting scientific questions about this process, and by isolating cells undergoing reprogramming, we may be able to make new discoveries about how the process occurs."
In addition to those already mentioned, the project also included graduate student Ted Lee and research technician Marissa Cooke of Georgia Tech, researcher Jamie Chilton of ArunA, and Weiqiang Chen and Jianping Fu of the University of Michigan.
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The above story is reprinted from materials provided by Georgia Institute of Technology. The original article was written by John Toon.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/_PdX2umSglQ/130407133312.htm
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By Kate Kelland
LONDON (Reuters) - The world's first clinical trial designed to explore using a hallucinogen from magic mushrooms to treat people with depression has stalled because of British and European rules on the use of illegal drugs in research.
David Nutt, president of the British Neuroscience Association and professor of neuropsychopharmacology at Imperial College London, said he had been granted an ethical green light and funding for the trial, but regulations were blocking it.
"We live in a world of insanity in terms of regulating drugs," he told a neuroscience conference in London on Sunday.
He has previously conducted small experiments on healthy volunteers and found that psilocybin, the psychedelic ingredient in magic mushrooms, has the potential to alleviate severe forms of depression in people who don't respond to other treatments.
Following these promising early results he was awarded a 550,000 pounds ($844,000) grant from the UK's Medical Research Council to conduct a full clinical trial in patients.
But psilocybin is illegal in Britain, and under the United Nations 1971 Convention on Psychotropic Substances it is classified as a Schedule 1 drug - one that has a high potential for abuse and no recognized medical use.
This, Nutt explained, means scientists need a special license to use magic mushrooms for trials in Britain, and the manufacture of a synthetic form of psilocybin for use in patients is tightly controlled by European Union regulations.
Together, this has meant he has so far been unable to find a company able to make and supply the drug for his trial, he said.
"Finding companies who could manufacture the drug and who are prepared to go through the regulatory hoops to get the license, which can take up to a year and triple the price, is proving very difficult," he said.
Nutt said regulatory authorities have a "primitive, old-fashioned attitude that Schedule 1 drugs could never have therapeutic potential", despite the fact that his research and the work done by other teams suggests such drugs may help treat some patients with psychiatric disorders.
Psilocybin - or "magic" - mushrooms grow naturally around the world and have been widely used since ancient times for religious rites and also for recreation.
Researchers in the United States have seen positive results in trials using MDMA, a pure form of the party drug ecstasy, in treating post-traumatic stress disorder.
"What we are trying to do is to tap into the reservoir of under-researched illegal drugs to see if we can find new and beneficial uses for them in people whose lives are often severely affected by illnesses such as depression," Nutt said.
The proposed trial would involve 60 patients with depression who have failed two previous treatments.
During two or three controlled sessions with a therapist, half would be given a synthetic form of psilocybin, and the other 30 a placebo. They would have guided talking therapy to explore negative thinking and issues troubling them, and doctors would follow them up for at least a year.
Nutt secured ethical approval for the trial in March.
In previous research, Nutt found that when healthy volunteers were injected with psilocybin, the drug switched off a part of the brain called the anterior cingulate cortex, which is known to be overactive in people with depression.
"Even in normal people, the more that part of the brain was switched off under the influence of the drug, the better they felt two weeks later. So there was a relationship between that transient switching off of the brain circuit and their subsequent mood,", he said. "This is the basis on which we want to run the trial."
(Reporting by Kate Kelland, editing by Richard Meares)
Source: http://news.yahoo.com/first-magic-mushroom-depression-trial-hits-stumbling-block-231805511.html
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By BY ESTHER HAMMER |
Published: April 4, 2013
All the drawings are part of Pearce?s Rays Baseball series. In most of her drawings, the face is not the distinguishing feature. It?s all about the movement and the stance.
This is the first solo show for the octogenarian artist, who displays an uncanny ability to capture the nuance of the play, whether it?s sliding into home plate, or jumping for joy after hitting a homer.
The public is invited to meet the artist and see her work at a free reception from 5 to 7 p.m. Friday, April 12, at the TECO Public Art Gallery, 702 N. Franklin St. in downtown Tampa. The exhibit is up through April 30.
For information email Debra Radke at dradke1@tampabay.rr.com.
Young artists display talents The University of Tampa presents its Annual Juried Student Art Exhibition through April 25 at the Scarfone/Hartley Gallery. This is the public?s chance to see what the new batch of artists springing onto the scene has to offer in originality and talent.
Ann Larson, acting director of Leepa-Ratner Museum of Art, served as judge in determining which artists won cash awards.
The Scarfone/Hartley Gallery is in the R K Baily Art Studios, 310 North Boulevard on the University of Tampa Campus. Call (813) 253-6217 for hours and information.
?Paths of Nature? remains through April The exhibit ?Paths of Nature? at Clayton Galleries in South Tampa will hold over until April 30.
?There has been a lot of positive response to this exhibition, so we decided to leave it up longer to give more people a chance to see it,? said gallery Director Mark Feingold.
Originally scheduled to end next week, the exhibit complements the spring season with scenes of warm Italian rooftops, red sunsets on blue water, and newly-leafed trees along a riverbed.
See it at Clayton Galleries, 4105 S. MacDill Ave. Call (813) 831-3753 for details.
Metal sculptures exhibit This is the last weekend to see ?Off the Ground: Two Decades of Table Sculptures,? featuring clever configurations by resident metal sculptor Dominique Labauvie. The times to visit are 1 to 5 p.m. today and 2 o 5 p.m. Sunday. The place is Bleu Acier, a working studio and gallery space at 109 W Columbus Drive in Tampa Heights. Call the gallery at (813) 215-0622.
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Happening next Tuesday at Concord International School:
The Hope Heart Institute, Stockbox Neighborhood Grocery and Molina Healthcare will host a FREE Family Health & Fitness Night at Concord International Elementary School on April 9th from 5:30pm-8:00pm to teach over 150 students and their families about healthy eating, active living and heart health. The evening will include dinner, games, prizes, and health tips. Watch students blend a smoothie by pedaling a bike, or dance their way to fitness with a local Zumba instructor!
Community organizations participating include:|
Guelaguetza- Student Performance
Sea Mar Dental
Washington State Dairy Council
Seattle Nutrition Action Consortium
Cascade Bicycle Club
Get Sound Yoga
SPIARC
YMCA
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MUMBAI, India (AP) ? A building that was being constructed illegally in a Mumbai, India, suburb has collapsed, and at least 27 people have died.
Police Inspector Digamber Jangale said 54 people were injured in the collapse Thursday evening in the Mumbai suburb of Thane. Rescuers were searching for more casualties in the debris early Friday.
He said the building did not have clearances from local authorities to be built. The first four floors had residences and offices that were occupied at the time of the collapse.
Workers also were adding four more floors and had finished three before the building fell.
Why it collapsed was not yet known.
Source: http://news.yahoo.com/building-collapses-india-least-27-killed-025427964.html
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via BuzzFeed
Our pre-caffeine roundup is a collection of the hottest, strangest, and most amusing stories of the morning.
What can we expect from today's big announcement from Facebook?Here are some purported ?Facebook Home? leaks which show an attractive-looking Android UI.
Speaking of Facebook: Holy crud, is this Mark Zuckerberg?s embarrassing childhood Angelfire website?
Meanwhile, here's Bill Gates and Paul Allen recreating an iconic 1981 Microsoft photo.
Well, that's unfortunate (to say the least): Sexual assaults involving social media are skyrocketing.
Samsung is building a bunch of boutique stores inside Best Buy.
Everyone's freaking out about Disney shutting down LucasArts ... and the fate of "Star Wars 1313" is still unknown!
Space Auction! You can buy Buzz Aldrin?s toothbrush or an armrest that has spent more time on the moon than any other armrest.
One more time: can Daft Punk make albums matter again?
Here's how Metafilter brought a deceased father's jokes back to life.
In closing: You wont' hear these corgis wining about not getting into the college of their choice!
Compiled by Helen A.S. Popkin, who invites you to join her on Twitter and/or Facebook.
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Allen West is on a mission.
"We are going to expose the other side for the racists that they are!" boomed West to a small audience crammed into a hotel conference room in National Harbor, Md., in March. The black Republican former congressman was there to raise money for the Allen West Foundation, a group he established after losing a tough re-election effort last year.
West hopes to spend $6 million on the midterm elections in 2014 to support and mentor 12 conservative candidates who are either minorities or have served in the military. While he commends the Republican Party for its attempt to bring more minorities into the fold, he seems to lack faith in its ability to pull it off. According to West, Republicans didn't give him the time of day when he first asked for support.
"There's fertile ground there, and I'm not going to sit back there and wait for them. I'm going to do it myself," West told Yahoo News. "I don't want people to have to struggle as I did. I want them to know that there's a place that they can come to for assistance so I can be an advocate for them to help them out."
Despite being knocked out of his seat after a single term by then-28-year-old Patrick Murphy last year, West has retained his rock star street cred with movement conservatives. When he attended the Conservative Political Action Conference in March, where he gave the rousing, early-morning speech, fans besieged him with requests for pictures and autographs.
During his brief tenure in the House, West quickly developed a reputation for shooting from the hip, plunging headfirst into noisy disputes with Democrats that made for fine cable news catnip. But now that he's no longer in office, West is free to take his rhetoric to a whole new level.
"I finally get to be a regular guy," West said. "It's great."
During his speech at the conference, for instance, West pointed to the American triumph over Naziism in World War II as an example of how the nation would survive President Barack Obama?s presidency. "When an unstoppable Nazi regime and war machine threatened to extinguish the light of free nations, we triumphed," West told the audience of conservative activists. "And ladies and gentlemen, when Barack Obama packs his bags and makes a hasty retreat back to Chicago, we will persevere."
It?s not standard practice for statesmen?even former ones?to drop the name of Hitler and the sitting president in the same breath, but West said he was making an important point. "You can say whatever you want; what I'm saying is that we've had challenges," West had told Yahoo News after the speech. "We have a president that is managing the demise of America. Our economic demise, our energy demise, our national security demise. If we can't talk about that as a challenge, I don't care what people say."
In his new life as a private citizen, West co-hosts an online talk show that launched earlier this year on the website Pajamas Media, which gives him hours to pontificate?and spout off about anything he wants.
During discussions on the show with co-hosts Michelle Fields and John Phillips, West doesn?t hold back from taking shots at media figures and politicians. On a recent episode, he called New York City Mayor Michael Bloomberg a "gnome" and joked that short people "should not be in political office." In another episode, he called MSNBC host Tour? Neblett a "coward" and a "punk." He also mocked Fox News' Brit Hume for wearing a pink shirt on TV.
"Not a fan of salmon?" Phillips asked him after a brief rant about Hume?s clothing.
"Eating salmon," West replied. "Not watching, you know, a guy dressed in salmon."
Later, West described the horror he faced watching a Calvin Klein ad with a male model in underwear. "I was like ewww, you know?" he said.
"Am I an anti-gay person?" he once asked Fields and Phillips during a discussion about same-sex marriage on the show. (West supports civil unions, but not changing the definition of marriage.) They both assured him this was not the case. "But that's what the media will say about me," West responded. "Well, they say a lot of things," Phillips said. West turned and looked directly into the camera. "Bastard," he said, ambiguously.
During another show, West offered his solution to Cyprus' banking problems. "If they had the Second Amendment in Cyprus," he said, "there is no way they could do this."
Fields, who sits across from West on the show and often laughs nervously after West makes some of his more off-color comments, said West acts like a new man in the aftermath of his race with Murphy.
"I feel like his guard has come down," Fields told Yahoo News. "He's so much more relaxed and so much more personable now that he's on the show. It's probably just the stress of the election that got to him, and now it's wonderful that we have an opportunity to see who Allen really is."
West is making no immediate plans to run for office, but says he may re-enter the arena "when the time is right." What that means exactly is up to interpretation. (He's fond of pointing to another young politician, Abraham Lincoln, who, like West, served only a single term in Congress. So stay tuned.)
For now, he plans to focus on his new organization and growing the audience of the online show. And no one, he says, will tell him what to say.
"I'm gonna say what I want to say anyhow, but yeah, the interesting thing is I have a platform," he said. "Losing a congressional race does not mean that you've defeated me."
Source: http://news.yahoo.com/blogs/ticket/allen-west-uncut-finally-regular-guy-093029108--politics.html
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What happens now?
South Korean Army soldiers patrol along a barbed-wire fence near the border village of Panmunjom in Paju, South Korea, Wednesday. North Korea said Wednesday that it had cut off a key military hot line with South Korea that allows cross-border travel to a jointly run industrial complex in the North.
Ahn Young-joon/AP
EnlargeNorth Korea's edgy game of war talk continued?at ever higher volumes today with the announcement that it will cut off the last military hot line with South Korea.
Skip to next paragraph Robert MarquandStaff writer
Over the past three decades, Robert Marquand has reported on a wide variety of subjects for?The Christian Science Monitor, including American education reform,?the wars in the Balkans, the Supreme Court, South Asian politics, and the oft-cited "rise of China." In the past 15 years he has served as the Monitor's bureau chief in Paris, Beijing, and New Delhi.?
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?Under the situation where a war may break out any moment, there is no need to keep North-South military communications,? said the regime, according to the Korean Central News Agency in Pyongyang.
The severed line of communication comes as the North, under young and new President Kim Jong-un, has said it is moving into its highest military alert status and has threatened to target Hawaii and Guam with rockets, after last month conducting its third nuclear test.?
The escalating rhetoric has brought a new agreement between US and South Korean officials that would dictate military action should the North cross the border, shell islands, or harm shipping in the kind of low-level actions Pyongyang has attempted in recent years.?
US military officials called the North Korean statement ?bellicose.??Many have expressed doubt that North Korea?s rockets have the range to reach US bases in Guam and Hawaii, but a few, including the?editor of Jane?s Defense Weekly, estimated they could reach US military bases in Japan, according to USA Today.?
Yesterday the small, poor state that is anchored by devotion to the Kim family dynasty, and is now nearly entirely dependent on China for basic sustenance but has also devoted considerable resources to its military, repeated a longstanding threat to turn Seoul into a ?sea of fire,? among other similarly colorful threats.
Earlier this year, the North said it would no longer answer?a hot line at the Demilitarized Zone. The hot line that the country is now threatening to shut down linked the two Koreas at the?Kaesong industrial park, created in the North during the warming winds of unification in the 2000s. The economic complex has long been a symbol of the potential for North-South cooperation.?
The New York Times today notes the North?s threat on the hot line follows comments from?Park Geun-hye,?the newly elected president of South Korea, that North Korea needed to end its nuclear threats in order to gain better traction with the South:
?If North Korea provokes or does things that harm peace, we must make sure that it gets nothing but will pay the price, while if it keeps its promises, the South should do the same,? she said during a briefing from her government?s top diplomats and North Korea policy-makers. ?Without rushing and in the same way we would lay one brick after another, we must develop South-North relations step by step, based on trust, and create sustainable peace.?
Scott Snyder of the Council on Foreign Relations in Washington, a veteran Korea-watcher once based in Seoul, tells The Christian Science Monitor that Pyongyang's main grievance appears to be recent United Nations sanctions targeted at the North.
Mr. Snyder argues that the meaning of the North?s sudden blustery behavior will only become clearer ?once the question of the consolidation of [Kim Jong-un?s] power becomes clearer.?
Agence France-Presse today said that a significant meeting among party elites and power brokers in the closed world of Pyongyang is about to take place.
"They will discuss how to handle the nuclear issue, inter-Korean relations and North Korea's longstanding demand for a peace treaty with the United States," Professor Yang Moo-jin of the University of North Korean Studies in Seoul told AFP.
Comparisons between the new Kim and his grandfather, Kim Il-sung, the patriarch of North Korea, are flowing freely, since there is a resemblance between the two. But Snyder notes that too little is yet known of the young Kim, who took over from his father Kim Jong-il last year, and that his youth is not necessarily a plus in such a high-stakes game.
?Right now the song is the same, but the volume is a lot louder. We don?t know his risk tolerance yet ? does he understand the game he is playing??
The US-South Korea military agreement follows a recent scrapping by the North of the historic legal armistice that effectively ended the Korean war in the 1950s. It came on the anniversary of the infamous sinking of the Choenan Navy vessel in 2010, which resulted in the deaths of 46 South Korean sailors, something that has had powerful emotional resonance in the South. (The Choenan was raised from the ocean floor, and forensics by the South claim the vessel was torpedoed by the North, something the North denies.)?
USA Today quotes an Asia-watcher who feels the key to dealing with Pyongyang runs through Beijing:
US diplomats should talk to their Chinese counterparts and say, "Your ally North Korea is acting in a very belligerent and destabilizing way," said [Richard] Bush, who heads the Brookings Institution Center for Northeast Asian Policy Studies. "They're acting in ways that are contrary to the principles you [China] have laid out. The situation is somewhat dangerous. You need to restrain your ally."
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MOSCOW (AP) ? A prominent Russian graffiti artist who hid his identity under the alias Pasha P183 and has been compared to Britain's Banksy for his bold style and anonymity has died. He was 29.
The Teatralnoye Delo theatrical production company, which recently commissioned Pasha P183 to create scenery for the musical "Todd," said the artist died Monday in Moscow. It wouldn't elaborate.
Teatralnoye Delo's spokeswoman Regina Vartsan, who knew the artist personally, described him Wednesday as a "sincere and open person of remarkable talent and unique vision."
One of his most famous works featured a huge pair of glasses painted on a snow-covered yard with a lamppost serving as one arm. Another piece showed chocolate bars painted on concrete, an image he said reflected the commercialization of art and life.
Source: http://news.yahoo.com/street-artist-dubbed-russian-banksy-dies-141056718.html
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Apr. 3, 2013 ? Treating patients with cells may one day become as common as it is now to treat the sick with drugs made from engineered proteins, antibodies or smaller chemicals, according to UC San Francisco researchers. They outlined their vision of cell-based therapeutics as a "third pillar of medicine" in an article published online April 3 in Science Translational Medicine.
"Today, biomedical science sits on the cusp of a revolution: the use of human and microbial cells as therapeutic entities," said Wendell Lim, PhD, a UCSF professor and director of the UCSF Center for Systems and Synthetic Biology, and one of the article's co-authors.
Cell therapies have the potential to address critical, unmet needs in the treatment of some of the deadliest diseases, including diabetes, cancer and inflammatory bowel diseases, the scientists said.
The reason, they said, is that cells can carry out functions that can't be performed by small-molecule drugs produced by Big Pharma, or by targeted drugs developed by biotech firms in the wake of the genetic engineering revolution. For one, cells are adaptable. They can sense their surroundings better than today's drugs and can vary their responses to better suit physiologic conditions.
Continued advances in cellular engineering could provide a framework, according to the co-authors, for the development of cellular therapies that are safe and that act predictably.
Joining Lim as co-authors of the Science Translational Medicine article are Michael Fischbach, PhD, assistant professor in the UCSF School of Pharmacy and an expert on the human microbiome, and Jeffrey Bluestone, PhD, executive vice chancellor and provost at UCSF and a leading diabetes and transplant rejection researcher.
The three also have organized a daylong symposium on the potential of cell therapy on April 12, 2013, supported by UCSF and the journal Science Translational Medicine, featuring talks and discussion by some of the nation's leading scientists in stem cell therapy, immunotherapy and the human microbiome -- the latter consisting primarily of the many hundreds of interacting species of bacteria that live within and upon us.
It has been more than four decades since cells were first used successfully in bone marrow and organ transplants, but the strategies envisioned today are more complex, involving manipulating cells based on new knowledge of how genes program their development and inner workings.
Cells of the immune system are among those that naturally carry out critical functions, but researchers are working on manipulating them to create better-targeted and more effective therapies. For instance, immune responses directed against cancer often are weak, so scientists are engineering and growing populations of immune cells that target specific molecules found on cancer cells. Already, remarkable recoveries from deadly leukemia have been credited to these new experimental treatments.
Bacterial cells also are showing promise for therapy. In recent years scientists have come to appreciate that 90 percent of the cells living within and on our bodies are bacteria and that these microbes interact with our own cells and affect our health.
The potential of bacteria to treat disease has been demonstrated dramatically by the recent use of fecal transplants to introduce communities of health-promoting bacteria into patients with recurrent Clostridium difficile infections, a serious gastrointestinal condition that can be life-threatening. Combinations of bacteria that also are engineered to fight inflammation might prove to be even more effective in treating Crohn's disease and other inflammatory bowel diseases, according to the UCSF scientists.
Other "killer apps" for cell therapies might include combinations of bacterial and human engineered cells. For instance, to control weight gain, gut bacteria might be deployed to convert certain carbohydrates into non-digestible forms, and also to signal engineered human cells lining the epithelial walls to trigger a program that sends a message to the brain that appetite has been satisfied.
Still, many engineering and regulatory challenges to cell therapy remain, the authors concede. Scientists want to be able to reliably control many aspects of cells, including their activation, population growth, programmed death, migration to specific sites in the body, interactions and communications with other cells, production of small therapeutic molecules, and decision making.
While the complexity of cells makes many scientists leery of cell therapies, the authors said, this complexity might make cell therapies more predictable than other drugs, because complicated, naturally occurring feedback circuits tend to restrict cellular activity. Just as cells already use molecular circuits to act very precisely, researchers ought to be able develop a systematic understanding of the cell's control modules to tune and reshape how cells behave.
"If small molecules and biologics are tools, then cells are carpenters -- and architects and engineers as well," Fischbach said.
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