Frank Ocean, Mumford & Sons, Fun., Black Keys and Jack White are all vying for the top prize on Sunday.
By Gil Kaufman, with additional reporting by Rob Markman and James Montgomery
Patrick Carney of The Black Keys
Photo: Matt Kent
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Due to chemotherapy resistance and a high rate of relapse, triple negative cancers are among the most difficult breast cancers to treat. In this issue of the Journal of Clinical Investigation, researchers led by Carlos Arteaga at Vanderbilt University identified a protein, TGF-?, that is highly expressed in triple negative breast cancer cells after chemotherapy. In a mouse model of breast cancer, TGF-? both diverted cells down a path to becoming cancerous and allowed for cancer to come back after treatment. Importantly, loss of TGF-? prevented tumor recurrence in mice. These studies identify a mechanism by which cancer cells elude standard chemotherapy and provide a rationale for testing the therapeutic potential of agents that block TGF-?.
Source: http://www.sciencecodex.com/rooting_out_recurrent_breast_cancer-106549
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Feb. 7, 2013 ? By identifying two genes required for transforming inorganic into organic mercury, which is far more toxic, scientists?have just taken a significant step toward protecting human health.
The question of how methylmercury, an organic form of mercury, is produced by natural processes in the environment has stumped scientists for decades, but a team led by researchers at Oak Ridge National Laboratory has solved the puzzle. Results of the study, published in the journal Science, provide the genetic basis for this process, known as microbial mercury methylation, and have far-reaching implications.
"Until now, we did not know how the bacteria convert mercury from natural and industrial processes into methylmercury," said ORNL's Liyuan Liang, a co-author and leader of a large Department of Energy-funded mercury research program that includes researchers from the University of Missouri-Columbia and University of Tennessee.
"This newly gained knowledge will allow scientists to study proteins responsible for the conversion process and learn what controls the activity," said Liang, adding that it may lead to ways of limiting methylmercury production in the environment.
For some 40 years scientists have known that when mercury is released into the environment certain bacteria can transform it into highly toxic methylmercury. Exactly how bacteria make this happen has eluded scientists. The challenge was to find proteins that can transfer a certain type of methyl group and to identify the genes responsible for their production.
Ultimately, by combining chemical principles and genome sequences, the team identified two genes, which they named hgcA and hgcB. Researchers experimentally deleted these genes one at a time from two strains of bacteria, which caused the resulting mutants to lose the ability to produce methylmercury. Reinserting these genes restored that capability, thus verifying the discovery.
The researchers found that this two-gene cluster is present in all known mercury-methylating bacteria, and they predicted that more than 50 other microorganisms may methylate mercury because they have a pair of similar genes.
Another key to the development was the collection of talent assembled to work on this problem.
"This discovery was made possible by our diverse team, which includes scientists with expertise in chemistry, computational biology, microbiology, neutron science, biochemistry and bacterial genetics," said Liang, who rated this paper as one of the most satisfying of her career.
Mercury is a toxin that spreads around the globe mainly through the burning of coal, industrial use and through natural processes such as volcanic eruptions. The chemical element bioaccumulates in aquatic food chains, especially in large fish. Various forms of mercury are widely found in sediments and water.
In a report just released by the United Nations Environmental Programme, Achiim Steiner, United Nations under-secretary general and executive director of UNEP, notes that "mercury remains a major global, regional and national challenge in terms of threats to human health and the environment."
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The above story is reprinted from materials provided by DOE/Oak Ridge National Laboratory.
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Let?s face it: HTC may have its hopes pinned on its not-so-secretive M7 smartphone, but that sooner or later the company is going to have to drop the codename and let it fly under another banner. As it turns out, that new name may be more familiar than expected ? prolific leaker EvLeaks noted on Twitter just a little while ago that it would debut simply as the HTC One later this month.Source: http://feedproxy.google.com/~r/Techcrunch/~3/WdcM1K9Mtok/
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MIAMI (AP) ? A Miami woman has been jailed on contempt charges after flipping off a judge during a drug possession hearing.
Miami television station NBC 6 (http://bit.ly/WNQ60c ) reported that 18-year-old Penelope Soto laughed Monday when Circuit Judge Jorge Rodriguez-Chomat asked how much her jewelry was worth as he inquired about her financial assets.
The judge told Soto to be serious and Soto said she was being serious.
He set Soto's bond at $5,000 and said bye-bye. Soto laughed again and replied, "adios." He summoned her back and reset her bond at $10,000.
Soto asked whether the judge was serious and he said, "I am serious. Adios."
Soto flipped him off and blurted an expletive as she walked away.
The judge summoned her again and sentenced her to 30 days in jail.
Source: http://news.yahoo.com/miami-woman-jailed-flipping-off-judge-232040888.html
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The Postal Service may no longer deliver letters on Saturdays, but that doesn't mean its services are not important.
In fact, the world would be a sad place without the post office and much of what it does would be sorely missed.
Check out these 9 reasons why the Postal Service is not obsolete yet:
Also on HuffPost:
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Ramallah Ballet Center owner Shyrine Ziadeh decided not to leave the West Bank to study dance, but instead opened a space to cultivate talent and hope among local youth.
Shyrine Ziadeh leads one of her three classes at the Ramallah Ballet Center, which she opened in December 2011 with the help of her family.
Christa Case Bryant/The Christian Science Monitor
Enlarge PhotosThe Ramallah Ballet Center, where girls in white tights and pink tutus twirl in front of a long mirror, seems a world away from the street below, where butchered lambs hang for sale, resentment lingers from the last intifada, and horns blare as cars snake dangerously close to each other in the narrow streets.?
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?Doesn?t the music make you feel so peaceful?? asks studio owner Shyrine Ziadeh, as she surveys her students. ?That?s one of my favorite things about dancing.??
Ms. Ziadeh?s dance studio is the first to open in Ramallah and the only one she knows of in the West Bank, following years of foreign instructors teaching lessons out of their homes or in local schools. (Read more about female entrepreneurs in the West Bank here.)
Ziadeh, who grew up in Ramallah, planned to leave the West Bank to study dance abroad after graduating from Birzeit University four years ago. But she changed her mind after she opened the studio last year and saw how popular her classes are. If she leaves, she fears no one will be there for the students.
?The kids here, they have many talents but no one to support them,? she says. ?So when I find a talented girl, I support her with all my heart.? Ziadeh says part of her motivation was the fact that when people around the world think of the Palestinian territories, they don?t see hope or talent, but violence.
Ziadeh sees her studio as place where local kids ? she teaches between 30 and 40 students a month ? can come to have fun in a safe place.
?I want to show the world that as Palestinians, we have talent and can defend our land not only in violence, but in the arts.?
Ziadeh sees the studio as a success, though it?s not yet profitable. She charges 200 shekels (about $55) a month for two classes a week, but some parents can?t afford to pay. The Orthodox Church that owns the studio space has so far allowed her to pay rent late when needed and she?s still repaying a loan her parents gave her.?
Some Israelis who heard about her business offered to give funding, something she?s so far declined in the hopes that Palestinians will be the ones to provide support.
In a region where the political conflict is reflected in so much of society Ziadeh says Israeli-Palestinian politics have complicated her business. She can?t get the costumes she needs because West Bank stores don?t sell them and she doesn?t have a permit to travel 15 miles to Jerusalem to buy them. Instead, she goes to Amman, Jordan to buy the outfits necessary for performances, or has them made by hand.
Another challenge Ziadeh hopes to overcome is gender. Her classes have been predominately female, but she thinks it?s important to involve boys as well because of the impact dance can have on them. She hopes that boys will start to enroll if she offers hip-hop classes.
?The problem is not with the Arab culture,? she says, citing a friend who teaches more boys than girls in the Egyptian royal ballet. ?I think it?s here, the boys want to be more tough.?
Being ready for an intifada is a prominent part of how boys are raised, she says. ?[They say] ?how can I dance when I have to defend my country?? But they can defend the country by dancing,? Ziadeh says.
Fadia Othman, the mother of one of Ziadeh?s students, says the classes help her 6-year-old daughter to be calmer in school.
Hadeel Kamil, a German-Palestinian gum surgeon who also has a daughter in the class, praises the decision of people like Ziadeh who stay in the Palestinian territories, sharing their talents locally instead of moving to a potentially easier and more lucrative life abroad.
"Palestine deserves people who know how to think," Ms. Kamil says.
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